New cells have been identified deep within the human lungs by researchers at the Perelman School of Medicine, University of Pennsylvania. In humans, the cell is thought to have a major role in the development of lung disease.
The novel cells, which scientists name respiratory airway secretory cells, were discovered by analysing human lung tissue. The oxygen-to-carbon dioxide exchange occurs in the lungs’ deep alveoli structures, where the cells are physiologically strung together in small airway branches.
In this study, researchers found that pulmonary airway secretory cells contain stem-like qualities that allow them to replenish other alveolar cells. Smoking and prevalent smoking-related ailments like COPD have been linked to a decrease in the ability of respiratory airway secretory cells to regenerate. This suggests that treating COPD by repairing the damage is a viable option.
Even though COPD is debilitating on a clinical level and often encountered, little is known about the molecular biology behind its occurrence. There are novel cell types that are damaged in COPD that might lead to the creation of new medicines if they can be identified and studied.
Patients with COPD often have alveolar destruction and loss, which is exacerbated by persistent inflammation. Over 10 percent of people in some regions of the United States are thought to have the illness, which is linked to nearly 3 million fatalities worldwide each year. These medicines can only delay the course of the disease rather than reverse or terminate it, hence they are frequently used in combination with steroid anti-inflammatory medications and oxygen therapy.
The progression of COPD in mice is only partially understood since the usual lab animal lacks crucial traits that are present in human lungs..